Nemesis was created by the European Branch of the Umbrella Corporation's pharmaceutical company. He was designed to have immense strength and power, yet to also be intelligent enough to follow orders and overcome obstacles, but not intelligent enough to rebel. This particular Nemesis was deployed to Raccoon City to kill any remaining members of the S.T.A.R.S. unit, which had become an annoyance for the corporation. His first victim was Brad Vickers, whom he impaled through the mouth with a tentacle.
Nemesis targeted Jill Valentine as his next victim. Jill managed to evade Nemesis throughout the city, but Nemesis continued to come after her, effortlessly taking down any obstacles in his way. After he shot down a rescue chopper and infected Jill with the T-Virus, Jill was forced to confront her attacker, managing to beat him with a barrage of explosives.
Nemesis wasn't truly gone. His jacket burning off signaled his second mutation. Continuing to chase a now cured Jill, she stopped him again by drowning him in chemicals in a waste management facility. Nemesis survived as a hunk of dissolving flesh, and devoured a dead Tyrant, mutating again into a huge tentacled monster. Jill managed to defeat Nemesis for good with the Rail Gun and a magnum to finish the job.
Nemesis is the focus of the first half of the third episode of Ultimate Assist Me!, in which Wesker helps Max master him, all the while trying to convince Max to replace Doom on his team with Nemesis, angering Doom. In the game, Nemesis moans to Wesker that he's hungry and wants tacos, all the while attacking Wesker with his tentacles. Wesker, enraged, snatches Max's arcadestick and procedes to pummel Nemesis into submission, ending the monster's portion of the video. In the end, when Wesker is revealed to be working with Galactus (Or M.O.D.O.K.) and Doom sends him into the game, Nemesis spots his master in his S.T.A.R.S. uniform and devours him by using his Level 3 Hyper combo.
- Ultimate Assist Me! Episode 5